张世卿,博士,副研究员。
毕业于南方医科大学获中药学学士学位和中药药理学硕士学位,2016年获香港浸会大学神经生物学博士学位并进行博士后研究,2019年获聘为香港浸会大学研究助理教授,2021年进入暨南大学药学院工作。主要开展中药和天然药物来源的神经系统疾病药物研究,以及神经系统疾病的病理机制研究。以第一作者/通讯作者在Advanced Science、ACS Appl Mater Interfaces、Pharmacol Res、Acta Pharmacol Sin、J Ginseng Res、Phytomedicine等期刊发表SCI论文23篇。主持国家自然科学基金青年科学基金项目1项,广东省自然科学基金青年提升项目和面上项目各1项。获中国神经修复学年会青年论坛优胜奖,并入选第72届德国林道诺贝尔奖获得者大会。
讲授课程
《国际药理学(全英)》
《制药生物技术》
《高级药理学》
研究方向
神经药理学及创新药物研发
主持项目
(1)国家自然科学基金-青年科学基金项目,81703728,2018年1月-2020年12月;
(2)广东省自然科学基金-青年提升项目,2023A1515030012,2023年01月-2025年12月;
(3)广东省自然科学基金-面上项目,2019A151501197,2019年10月-2022年9月。
代表性论文
[1] Zhang SQ#, Sun P#, Lin K#, Chan FHL, Gao Q, Lau WF, Roy VAL, Zhang HQ, Lai KWC*, Huang ZF*, Yung KKL*. Extracellular nanomatrix-induced self-organization of neural stem cells into miniature substantia nigra-like structures with therapeutic effects on Parkinsonian rats. Advanced Science. 2019, 6(24): 1901822.
[2] Wu X#, Yi X#, Zhao B, Zhi Y, Xu Z, Cao Y, Cao X, Pang J, Yung KKL, Zhang S*, Liu S*, Zhou P*. The volume-regulated anion channel regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function. Pharmacological Research. 2023, 198, 107016.
[3] Wang Y#, Tan Z#, Zhang Z, Zhu P, Tam SW, Zhang Z, Jiang X, Lin K, Tian L, Huang Z, Zhang S*, Peng YK*, Yung KKL*. Facet-dependent activity of CeO2 nanozymes regulate the fate of human neural progenitor cell via redox homeostasis. ACS Applied Materials & Interfaces. 2022, 14(31): 35423-35433.
[4] Lin KL#, Sze SCW#, Liu B, Zhang Z, Zhang Z, Zhu PL, Wong Y, Deng QD, Yung KKL*, Zhang SQ*. 20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis. Journal of Ginseng Research. 2021, 45: 325-333.
[5] Lin KL#, Liu B#, Lim SL, Fu XQ, Sze SCW, Yung KKL*, Zhang SQ*. 20(S)-protopanaxadiol promotes the migration, proliferation and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway. Journal of Ginseng Research. 2020, 44: 475-482.
[6] Wu X Y#, Lv J Y#, Zhang SQ#, Yi X, Xu ZW, Zhi YX, Zhao BX, Pang JX, Yung K*, Liu SW*, Zhou PZ*. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta pharmacologica Sinica. 2021, 10.1038/s41401-021-00739-9.
[7] Lin K#, Zhang Z#, Zhang Z#, Zhu P, Jiang X, Wang Y, Deng Q*, Lam Yung KK*, Zhang S*. Oleanolic acid alleviates cerebral ischemia/reperfusion injury via regulation of the GSK-3β/HO-1 signaling pathway. Pharmaceuticals. 2021, 15(1): 1.
[8] Jiang XL#, Deng B#, Deng SH#, Cai M, Tian ZB, Chen RX, Xu YC, Ding WJ, Xu HL, Zhang SW, Zhang SQ*, Liu B*, Zhang JZ*. Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src. Phytomedicine. 2022, 95:153705.
[9] Zhang SQ#, Jiang XL#, Wang Y, Lin KL, Zhang Z, Zhang Z, Ng ML, Qu SG, Sze SCW*, Yung KKL*. Protective Effect of An-Gong-Niu-Huang Wan Pre-treatment against Experimental Cerebral Ischemia Injury via Regulating GSK-3β/HO-1 Pathway. Frontiers in Pharmacology. 2021, 16, 640297.
[10] Zhang Z#, Zhang SQ#, Lui CNP, Zhu PL, Zhang Z, Lin KL, Dai YW*, Yung KKL*. Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease. Journal of Neurorestoratology. 2019, 07: 207-222.
代表性专利
(1)Yung K.K.L., Huang Z.F., Zhang S.Q. Biocompatible sculptured extracellular nanomatrix enables self assembly of neural stem cells into miniature brain organoids of substantia nigra, 2018.04.12, 美国专利, 16/209,934.
联系方式
联系邮箱:sqzhang@jnu.edu.cn