张君秋,女,博士。2016年毕业于中山大学,获理学学士学位。2022年毕业于得克萨斯大学西南医学中心(UT Southwestern Medical Center)肿瘤学专业,获博士学位。2022年进入暨南大学中药学博士后流动站进行博士后研究。主持国家自然科学基金青年基金项目1项。已发表SCI论文6篇,其中以第一作者发表的SCI论文1篇。
研究方向:
抗肿瘤活性分子的筛选、作用靶点和作用机制研究以及创新药物的研究开发。
主持的科研项目:
[1] 国家自然科学基金青年基金项目(项目编号:82304526, 主持)
代表性论文:
[1]Zhang J,Zhao X, Liu L, Li HD, Gu L, Castrillon DH, Li GM. The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks. Proc Natl Acad Sci U S A, 2022, 119(40):e2201738119.
[2] Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM. MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway. Cancer Cell, 2021, 39(1):109-121.
[3] Li HD, Lu C, Zhang H, Hu Q, Zhang J, Cuevas IC, Sahoo SS, Aguilar M, Maurais EG, Zhang S, Wang X, Akbay EA, Li GM, Li B, Koduru P, Ly P, Fu YX, Castrillon DH. A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response. JCI Insight, 2020, 5(14):e138829.
[4] Huang H, Wright S, Zhang J, Brekken RA. Getting a grip on adhesion: Cadherin switching and collagen signaling. Biochim Biophys Acta Mol Cell Res, 2019, 1866(11):118472.
[5] Wen Q, Huang M, Xie J, Liu R, Miao Q, Huang J, Zhang J, Lyu W, Qi M, Wu C, Qi Q, Zhang Z, Deng R, Wang C, Chen ZS, Zhang D, Ye W, Chen M. lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2. Drug Resist Updat, 2023, 69:100975.